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Alopecia: 5‐alpha‐reductase inhibitor treatment
Do you find treatment challenging for frontal fibrosing alopecia? Its treatment regimen often mirrors other lymphocytic‐predominant cicatricial alopecia. 5‐alpha‐reductase inhibitor has been reported with some treatment success in severe cases of frontal fibrosing alopecia, so researchers recently carried out an analysis of articles published on treatment efficacy and safety of 5‐alpha‐reductase inhibitor for the treatment of the hair loss condition.
Researchers reviewed articles published on the use of 5‐alpha‐reductase inhibitor to treat frontal fibrosing alopecia between 2005 and 2017. Two studies with moderate levels of evidence described the efficacy of 5‐alpha‐reductase inhibitor for the treatment of the condition. 5‐alpha‐reductase inhibitor was commonly used as adjunctive therapy with positive results in recalcitrant disease. Mild to moderate hair regrowth was reported in one grade 2 and three lower grade (one grade 3 and two grade 4) studies. There was limited evidence on the safety aspects of this medication in most studies.
The review demonstrated that frontal fibrosing alopecia patients treated with 5‐alpha‐reductase inhibitor could achieve either disease stability or reduction in the rate of progression in selected cases.
Murad, A. and Bergfeld, W. (2018), 5‐alpha‐reductase inhibitor treatment for frontal fibrosing alopecia: an evidence‐based treatment update. J Eur Acad Dermatol Venereol, 32: 1385-1390. doi:10.1111/jdv.14930
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